Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.

VEGFs activate 3 receptor tyrosine kinases, VEGFR-1, VEGFR-2, and VEGFR-3, promoting angiogenic and lymphangiogenic signaling. The extracellular receptor domain (ECD) consists of 7 Ig-homology domains; domains 2 and 3 (D23) represent the ligand-binding domain, whereas the function of D4-7 is unclear. Ligand binding promotes receptor dimerization and instigates transmembrane signaling and recept...

VASCULAR BIOLOGY Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

VEGFs activate 3 receptor tyrosine kinases, VEGFR-1, VEGFR-2, and VEGFR-3, promoting angiogenic and lymphangiogenic signaling. The extracellular receptor domain (ECD) consists of 7 Ig-homology domains; domains 2 and 3 (D23) represent the ligandbinding domain, whereas the function of D4-7 is unclear. Ligand binding promotes receptor dimerization and instigates transmembrane signaling and recepto...

Thermodynamic and structural description of allosterically regulated VEGF receptor 2 dimerization

Maurice S. Brozzo, Saša Bjelić, Kaisa Kisko, Thomas Schleier, Veli-Matti Leppänen, Kari Alitalo, Fritz K. Winkler and Kurt Ballmer-Hofer Paul Scherrer Institut, Molecular Cell Biology and Biomolecular Research CH-5232 Villigen PSI, Switzerland; Molecular Cancer Biology Program, Biomedicum Helsinki, Department of Pathology, Haartman Institute and Helsinki University Central Hospital, P.O.B. 63, ...

Structural evidence for dimerization-regulated activation of an integral membrane

Structural and thermodynamic properties of Alumina

We have investigated the electronic structure and thermodynamic properties of supercell of the -Al2O3 by first-principles calculation in framework of density functional theory (DFT) and full potential linearized augmented plane wave (FP-LAPW) with generalized gradient approximation (GGA) and by quasi-harmonic Debye model. Our calculated value for direct band gap of α-Al2O3 is 7.2 eV which i...